Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors
نویسندگان
چکیده
منابع مشابه
Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors
BACKGROUND Discovery of potent inhibitors of urease (jack bean) enzyme is the first step in the development of drugs against diseases caused by ureolytic enzyme. RESULTS Thirty-two derivatives of barbituric acid as zwitterionic adducts of diethyl ammonium salts were synthesized. All synthesized compounds (4a-z and 5a-s) were screened for their in vitro inhibition potential against urease enzy...
متن کاملGreen Synthesis and Urease Inhibitory Activity of Spiro-pyrimidinethiones/spiro-Pyrimidinones-barbituric Acid Derivatives
Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the Biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. Spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...
متن کاملGreen Synthesis and Urease Inhibitory Activity of Spiro-pyrimidinethiones/spiro-Pyrimidinones-barbituric Acid Derivatives
Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the Biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. Spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...
متن کاملGreen Synthesis and Urease Inhibitory Activity of Spiro-Pyrimidinethiones/Spiro-Pyrimidinones-Barbituric Acid Derivatives.
Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the Biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. Spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...
متن کاملgreen synthesis and urease inhibitory activity of spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives
sulfonic acid functionalized sba-15 (sba-pr-so3h) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...
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ژورنال
عنوان ژورنال: Chemistry Central Journal
سال: 2015
ISSN: 1752-153X
DOI: 10.1186/s13065-015-0140-1